Bioinformatics Platform

Recent publications


Seijo S, Lozano JJ, Alonso C, Miquel R, Berzigotti A, Reverter E, Turon F, Martinez-Chantar ML, Castro A, Mato JM, Hernández-Gea V, Bosch J,García-Pagan JC. Metabolomics as a diagnostic tool for idiopathic non-cirrhotic portal hypertension. Liver Int. 2015 Sep 23. doi: 10.1111/liv.12972. [Epub ahead of print]


Bonaccorsi-Riani E, Danger R, Lozano JJ, Martinez-Picola M, Kodela E,Mas-Malavila R, Bruguera M, Collins HL, Hider RC, Martinez-Llordella M,Sanchez-Fueyo A. Iron Deficiency Impairs Intra-Hepatic Lymphocyte Mediated Immune Response. PLoS One. 2015 Aug 19;10(8):e0136106. doi: 10.1371/journal.pone.0136106.eCollection 2015.


Blasi A, Beltran J, Martin N, Martinez-Palli G, Lozano JJ, Balust J,Torrents A, Taura P. Transient hyperglycemia during liver transplantation does not affect the early graft function. Ann Hepatol. 2015 Sep-Oct;14(5):675-87.


Torabi K, Miro R, Fernandez-Jimenez N, Quintanilla I, Ramos L, Prat E, Del Rey J, Pujol N, Killian JK, Meltzer PS, Fernandez PL, Ried T, Lozano JJ, Camps J, Ponsa I. Patterns of somatic uniparental disomy identify novel tumor suppressor genes in colorectal cancer. Carcinogenesis. 2015 Oct;36(10):1103-10. doi: 10.1093/carcin/bgv115. Epub 2015 Aug 4.


Dumontet E, Danger R, Vagefi PA, Londoño MC, Pallier A, Lozano JJ, Giral M, Degauque N, Soulillou JP, Martinez-Llordella M, Lee H, Latournerie M, Boudjema K, Dulong J, Tarte K, Sanchez-Fueyo A, Feng S, Brouard S, Conchon S. Peripheral phenotype and gene expression profiles of combined liver-kidney transplant patients. Liver Int. 2015 Jul 20. doi: 10.1111/liv.12917. [Epub ahead of print]


Coll M, El Taghdouini A, Perea L, Mannaerts I, Vila-Casadesus M, Blaya D, Rodrigo-Torres D,Affo S, Morales-Ibanez O, Graupera I, Lozano JJ, Najimi M, Sokal E, Lambrecht J, Ginès P, van Grunsven LA, Sancho-Bru P. Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells. Sci Rep. 2015 Jun 22;5:11549. doi: 10.1038/srep11549.


Marin-Aguilera M, Reig O, Lozano JJ, Jimenez N, Garcia-Recio S, Erill N, Gaba L, Tagliapietra A, Ortega V, Carrera G, Colomer A, Gascon P, Mellado B. Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer. Oncotarget. 2015 Apr 30;6(12):10604-16.


Cabezon R, Carrera-Silva EA, Florez-Grau G, Errasti AE, Calderon-Gomez E, Lozano JJ, Espana C, Ricart E, Panes J, Rothlin CV, Benitez-Ribas D. MERTK as negative regulator of human T cell activation. J Leukoc Biol. 2015 Apr;97(4):751-60. doi: 10.1189/jlb.3A0714-334R. Epub 2015 Jan 26.


Farres J, Llacuna L, Martin-Caballero J, Martinez C, Lozano JJ, Ampurdanes C,Lopez-Contreras AJ, Florensa L, Navarro J, Ottina E, Dantzer F, Schreiber V, Villunger A, Fernández-Capetillo O, Yelamos J. PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors. Cell Death Differ. 2015 Jul;22(7):1144-57. doi: 10.1038/cdd.2014.202. Epub 2014 Dec 12.


Esteban-Jurado C, Vila-Casadesus M, Garre P, Lozano JJ, Pristoupilova A, Beltran S, Munoz J, Ocana T, Balaguer F, Lopez-Ceron M, Cuatrecasas M, Franch-Exposito S, Pique JM, Castells A, Carracedo A, Ruiz-Ponte C, Abuli A, Bessa X, Andreu M, Bujanda L, Caldes T, Castellvi-Bel S. Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer. Genet Med. 2014 Jul 24. doi: 10.1038/gim.2014.89.


Bohne F, Londono MC, Benitez C, Miquel R, Martinez-Llordella M, Russo C, Ortiz C, Bonaccorsi-Riani E, Brander C, Bauer T, Protzer U, Jaeckel E, Taubert R, Forns X, Navasa M, Berenguer M, Rimola A, Lozano JJ, Sanchez-Fueyo A. HCV-Induced Immune Responses Influence the Development of Operational Tolerance After Liver Transplantation in Humans. Sci Transl Med. 2014 Jun 25;6(242):242ra81. doi:10.1126/scitranslmed.3008793.


Alonso-Espinaco V, Cuatrecasas M, Alonso V, Escudero P, Marmol M, Horndler C, Ortego J, Gallego R, Codony-Servat J, Garcia-Albeniz X, Jares P, Castells A, Lozano JJ, Rosell R, Maurel J. RAC1b overexpression correlates with poor prognosis in KRAS/BRAF WT metastatic colorectal cancer patients treated with first-line FOLFOX/XELOX chemotherapy. Eur J Cancer. 2014 Jul;50(11):1973-81. doi: 10.1016/j.ejca.2014.04.019. Epub 2014 May 12.


Leal RF, Planell N, Kajekar R, Lozano JJ, Ordas I, Dotti I, Esteller M, Masamunt MC, Parmar H, Ricart E, Panes J, Salas A. Identification of inflammatory mediators in patients with Crohn's disease unresponsive to anti-TNFa therapy. Gut. 2014 Apr 3. doi: 10.1136/gutjnl-2013-306518.


Rodrigo-Torres D, Affo S, Coll M, Morales-Ibanez O, Millan C, Blaya D, Alvarez-Guaita A, Rentero C, Lozano JJ, Maestro MA, Solar M, Arroyo V, Caballería J, van Grunsven LA, Enrich C, Gines P, Bataller R, Sancho-Bru P. The biliary epithelium gives rise to liver progenitor cells. Hepatology. 2014 Feb 20. doi: 10.1002/hep.27078.


Gonzalo V, Lozano JJ, Alonso-Espinaco V, Moreira L, Munoz J, Pellise M, Castellvi-Bel S, Bessa X, Andreu M, Xicola RM, Llor X, Ruiz-Ponte C, Carracedo A, Jover R, Castells A, Balaguer F Multiple Sporadic Colorectal Cancers Display a Unique Methylation Phenotype. PLoS One. 2014 Mar 18;9(3):e91033


Varela-Rey M, Iruarrizaga-Lejarreta M, Lozano JJ, Aransay AM, Fernandez AF, Lavin JL, Mosen-Ansorena D, Berdasco M, Turmaine M, Luka Z, Wagner C, Lu SC, Esteller M, Mirsky R, Jessen KR, Fraga MF, Martinez-Chantar ML, Mato JM, Woodhoo A.S-adenosylmethionine Levels Regulate the Schwann Cell DNA Methylome. Neuron. 2014 Mar 5;81(5):1024-39


Esteban-Jurado C, Garre P, Vila M, Lozano JJ, Pristoupilova A, Beltran S, Abuli A, Munoz J, Balaguer F, Ocana T, Castells A, Pique JM, Carracedo A, Ruiz-Ponte C, Bessa X, Andreu M, Bujanda L, Caldes T, Castellvi-Bel S. New genes emerging for colorectal cancer predisposition. World J Gastroenterol. 2014 Feb 28;20(8):1961-1971. Review


Marin-Aguilera M, Codony-Servat J, Reig O, Lozano JJ, Fernandez PL, Pereira MV, Jimenez N, Donovan M, Puig P, Mengual L, Bermudo R, Font A, Gallardo E,Ribal MJ, Alcaraz A, Gascon P, Mellado B. Epithelial-to-mesenchymal transition mediates docetaxel resistance and high risk of relapse in prostate cancer. Mol Cancer Ther. 2014 Mar 21. [Epub ahead of print]


Botta-Orfila T, Morato X, Compta Y, Lozano JJ, Falgas N, Valldeoriola F, Pont-Sunyer C, Vilas D, Mengual L, Fernandez M, Molinuevo JL, Antonell A, Marti MJ, Fernandez-Santiago R, Ezquerra M. Identification of blood serum micro-RNAs associated with idiopathic and LRRK2 Parkinson's disease. J Neurosci Res. 2014 Mar 20. doi: 10.1002/jnr.23377. [Epub ahead of print]


Berardis S, Lombard C, Evraerts J, El Taghdouini A, Rosseels V, Sancho-Bru P, Lozano JJ, van Grunsven L, Sokal E, Najimi M. Gene expression profiling and secretome analysis differentiate adult-derived human liver stem/progenitor cells and human hepatic stellate cells. PLoS One. 2014 Jan 21;9(1):e86137.


Mengual L, Ars E, Lozano JJ, Burset M, Izquierdo L, Ingelmo-Torres M, Gaya JM, Algaba F, Villavicencio H, Ribal MJ, Alcaraz A. Gene expression profiles in prostate cancer: Identification of candidate non-invasive diagnostic markers. Actas Urol Esp. 2013 Oct 24.


Calvo J, Sanchez-Cid L, Munoz M, Lozano JJ, Thomson TM, Fernandez PL. Infrequent loss of luminal differentiation in ductal breast cancer metastasis. PLoS One. 2013 Oct 21;8(10):e78097.


Izquierdo L, Ingelmo-Torres M, Mallofre C,Lozano JJ, Verhasselt-Crinquette M, Leroy X, Colin P, Comperat E, Roupret M, Alcaraz A, Mengual L. Prognostic Value Of Microrna Expression Pattern In Upper Tract Urothelial Carcinoma. BJU Int. 2013 Nov 1. doi: 10.1111/bju.12551.


Mengual L, Ribal MJ, Lozano JJ, Ingelmo-Torres M, Burset M, Fernandez PL,Alcaraz A. Validation study of a noninvasive urine test for diagnosis and prognosis assessment of bladder cancer: evidence for improved models. J Urol. 2014 Jan;191(1):261-9.


Tingaud-Sequeira A, Lozano JJ, Zapater C, Otero D, Kube M, Reinhardt R,Cerda J. A rapid transcriptome response is associated with desiccation resistance in aerially-exposed killifish embryos. PLoS One. 2013 May 31;8(5):e64410. doi: 10.1371/journal.pone.0064410.


Abuli A, Lozano JJ, Rodriguez-Soler M, Jover R, Bessa X, Munoz J,Esteban-Jurado C, Fernandez-Rozadilla C, Carracedo A, Ruiz-Ponte C, Cubiella J, Balaguer F, Bujanda L, Rene JM, Clofent J, Morillas JD, Nicolas-Perez D,Xicola RM, Llor X,Pique JM, Andreu M, Castells A, Castellví-Bel S; for the Gastrointestinal Oncology Group of the Spanish Gastroenterological Association. Genetic Susceptibility variants associated with colorrectal cancer prognosis. Carcinogenesis. 2013 May 27. [Epub ahead of print]


Mengual L, Lozano JJ, Ingelmo-Torres M, Gazquez C, Ribal MJ, Alcaraz A. Using microRNA profiling in urine samples to develop a non-invasive test for bladder cancer. Int J Cancer. 2013 May 17. doi: 10.1002/ijc.28274


Farres J, Martin-Caballero J, Martinez C, Lozano JJ, Llacuna L, Ampurdanes C, Ruiz-Herguido C, Dantzer F, Schreiber V, Villunger A, Bigas A,Yelamos J. PARP-2 is required to maintain hematopoiesis following sublethal γ-irradiation in mice. Blood. 2013 May 15.


Benitez C, Londono MC, Miquel R, Manzia TM, Abraldes JG, Lozano JJ, Martínez-Llordella M, López M, Angelico R, Bohne F, Sese P, Daoud F, Larcier P, Roelen DL, Claas F, Whitehouse G, Lerut J, Pirenne J, Rimola A, Tisone G, Sánchez-Fueyo A. Prospective multi-center clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients. Hepatology. 2013 Mar 26. doi: 10.1002/hep.26426. PMID:23532679


Lopez-Vicario C, Gonzalez-Periz A, Rius B, Moran-Salvador E, Garcia-Alonso V, Lozano JJ, Bataller R, Cofan M, Kang JX, Arroyo V, Claria J, Titos E. Molecular interplay between Δ5/Δ6 desaturases and long-chain fatty acids in the pathogenesis of non-alcoholic steatohepatitis. Gut. 2013 Mar 14. PMID:23492103


Link A, Balaguer F, Shen Y, Lozano JJ, Leung HC, Boland CR, Goel A. Curcumin modulates DNA methylation in colorectal cancer cells. PLoS One. 2013;8(2):e57709. PMID:23460897


Seijo S, Lozano JJ, Alonso C, Reverter E, Miquel R, Abraldes JG, Martinez-Chantar ML, Garcia-Criado A, Berzigotti A, Castro A, Mato JM, Bosch J, Garcia-Pagan JC. Metabolomics Discloses Potential Biomarkers for the Noninvasive Diagnosis of Idiopathic Portal Hypertension. Am J Gastroenterol. 2013 Feb 19. PMID:23419380


Giraldez MD, Lozano JJ, Ramírez G, Hijona E, Bujanda L, Castells A,Gironella M. Circulating MicroRNAs as Biomarkers of Colorectal Cancer: Results from a Genome-Wide Profiling and Validation Study. Clin Gastroenterol Hepatol. 2012 Dec 22. PMID:23267864


Jin S, Chin J, Seeber S, Niewoehner J, Weiser B, Beaucamp N, Woods J, Murphy C, Fanning A, Shanahan F, Nally K, Kajekar R, Salas A, Planell N, Lozano J,Panes J, Parmar H, Demartino J, Narula S, Thomas-Karyat DA. TL1A/TNFSF15 directly induces proinflammatory cytokines, including TNFα, from CD3+CD161+ T cells to exacerbate gut inflammation. Mucosal Immunol. 2012 Dec 19. PMID:23250276


Planell N, Lozano JJ, Mora-Buch R, Masamunt MC, Jimeno M, Ordas I, Esteller M, Ricart E, Pique JM, Panes J, Salas A. Transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission reveals lasting epithelial cell alterations. Gut. 2012 Nov 7. PMID:23135761


Revilla-Nuin B, Parrilla P, Lozano J, Martinez de Haro LF, Ortiz A, Martínez C, Munitiz V, Ruiz de Angulo D, Bermejo J, Molina J, Cayuela ML, Yelamos J. Predictive Value of MicroRNAs in the Progression of Barrett Esophagus to Adenocarcinoma in a Long-Term Follow-Up Study. Ann Surg. 2012 Oct 10.PMID:23059500


Vazquez-Chantada M, Gonzalez-Lahera A, Martinez-Arranz I, Garcia-Monzon C, Regueiro MM, Garcia-Rodriguez JL, Schlangen KA, Mendibil I, Rodriguez-Ezpeleta N, Lozano JJ, Banasik K, Justesen JM, Joergensen T, Witte DR, Lauritzen T, Hansen T, Pedersen O, Veyrie N, Clement K, Tordjman J, Tran A, Marchand-Brustel YL, Buque X, Aspichueta P, Echevarria-Uraga JJ, Martin-Duce A, Caballeria J, Gual P, Castro A, Mato JM, Martinez-Chantar ML, Aransay AM. Solute carrier family 2 member 1 (SLC2A1) is involved in the development of nonalcoholic fatty liver disease. Hepatology. 2012 Sep 7.PMID:22961556


Giraldez MD, Lozano JJ, Cuatrecasas M, Alonso-Espinaco V, Maurel J,Marmol M, Horndler C, Ortego J, Alonso V, Escudero P, Ramirez G, Petry C, Lasalvia L, Bohmann K, Wirtz R, Mira A, Castells A. Gene-expression signature of tumor recurrence in patients with stage II and III colon cancer treated with 5'fluoruracil-based adjuvant chemotherapy. Int J Cancer. 2012 Jul 26.PMID:22833293


Martinez-Lopez N, Garcia-Rodriguez JL, Varela-Rey M, Gutierrez V, Fernandez-Ramos D, Beraza N, Aransay AM, Schlangen K, Lozano JJ, Aspichueta P, Luka Z, Wagner C, Evert M, Calvisi DF, Lu SC, Mato JM, Martinez-Chantar ML. Hepatoma Cells from Mice Deficient in Glycine N-Methyltransferase Have Increased RAS Signaling and Activation of Liver Kinase B1. Gastroenterology. 2012 Jun 8.PMID:22687285


Affo S, Dominguez M, Lozano JJ, Sancho-Bru P, Rodrigo-Torres D, Morales-Ibanez O, Moreno M, Millan C, Loaeza-Del-Castillo A, Altamirano J, Garcia-Pagan JC, Arroyo V, Gines P, Caballeria J, Schwabe RF, Bataller R. Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis. Gut. 2012 May 25. PMID:22637703


Roman J, Planell N, Lozano JJ, Aceituno M, Esteller M, Pontes C, Balsa D, Merlos M, Panes J, Salas A. Evaluation of responsive gene expression as a sensitive and specific biomarker in patients with ulcerative colitis.Inflamm Bowel Dis. 2012 May 17. pdf


Lario S, Ramirez-Lazaro MJ, Aransay AM, Lozano JJ, Montserrat A, Casalots A, Junquera F, Alvarez J, Segura F, Campo R, Calvet X. microRNA profiling in duodenal ulcer disease caused by Helicobacter pylori infection in a Western population. Clin Microbiol Infect. 2012 Mar 24. PMID:22524533 pdf, mat supl


Celia-Terrassa T, Meca-Cortes O, Mateo F, Martinez de Paz A, Rubio N, Arnal-Estape A, Ell BJ, Bermudo R, Diaz A, Guerra-Rebollo M, Lozano JJ, Estaras C, Ulloa C, Rholvarez-Simon D, Mila J, Vilella R, Paciucci R, Martínez-Balbas M, Garcia de Herreros A, Gomis RR, Kang Y, Blanco J, Fernandez PL, Thomson TM. Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J Clin Invest. 2012 Apr 16. pii: 59218. doi: 10.1172/JCI59218. [Epub ahead of print] PMID:22505459 link


Iruarrizaga-Lejarreta M, Varela-Rey M, Lozano JJ, Fernandez-Ramos D, Rodriguez-Ezpeleta N, Embade N, Lu SC, van der Kraan PM, Blaney Davidson EN, Gorospe M, Mirsky R, Jessen KR, Aransay AM, Mato JM, Martinez-Chantar ML, Woodhoo A. The RNA-Binding Protein Human Antigen R Controls Global Changes in Gene Expression during Schwann Cell Development. J Neurosci. 2012 Apr 4;32(14):4944-4958.PMID:22492050. pdf


Mercader JM, Gonzalez JR, Lozano JJ, Bak M, Kauppinen S, Sumoy L, Dierssen M, Fernandez-Aranda F, Visa J, Gratacos M, Estivill X. Aberrant brain microRNA target and miRISC gene expression in the anx/anx anorexia mouse model.Gene. 2012 Jan 30.PMID:22310387


Danger R, Pallier A, Giral M, Martinez-Llordella M, Lozano JJ, Degauque N, Sanchez-Fueyo A, Soulillou JP, Brouard S. Upregulation of miR-142-3p in Peripheral Blood Mononuclear Cells of Operationally Tolerant Patients with a Renal Transplant. J Am Soc Nephrol. 2012 Jan 26. [Epub ahead of print]pdf


Sancho-Bru P, Altamirano J, Rodrigo-Torres D, Coll M, Millan C, Lozano JJ, Miquel R, Arroyo V, Caballeria J, Gines P, Bataller R. Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis. Hepatology. 2012 Jan 25. doi: 10.1002/hep.25614. [Epub ahead of print]. PMID:22278680 pdf


Bohne F, Martinez-Llordella M, Lozano JJ, Miquel R, Benitez C, Londono MC, Manzia TM, Angelico R, Swinkels DW, Tjalsma H, Lopez M, Abraldes JG, Bonaccorsi-Riani E, Jaeckel E, Taubert R, Pirenne J, Rimola A, Tisone G, Sanchez-Fueyo A. Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation. J Clin Invest. 2011 Dec 12. pii: 59411. doi: 10.1172/JCI59411 [Epub ahead of print]. PMID:22156196 link


Balaguer F, Moreira L, Lozano JJ, Link A, Ramirez G, Shen Y, Cuatrecasas M, Arnold M, Meltzer SJ, Syngal S, Stoffel E, Jover Martinez R, Llor X, Castells A, Boland CR, Gironella M, Goel A. Colorectal cancers with microsatellite instability display unique miRNA profiles. Clin Cancer Res. 2011 Aug 15. [Epub ahead of print]. PMID:21844009


Lozano JJ, Pallier A, Martinez-Llordella M, Danger R, López M, Giral M,Londono MC, Rimola A, Soulillou JP, Brouard S, Sánchez-Fueyo A. Comparison of Transcriptional and Blood Cell-Phenotypic Markers Between Operationally Tolerant Liver and Kidney Recipients. Am J Transplant. 2011 Aug 9. doi: 10.1111/j.1600-6143.2011.03638.x. [Epubahead of print] PMID:21827613


Llorens F, Hummel M, Pastor X, Ferrer A, Pluvinet R, Vivancos A, Castillo E,Iraola S, Mosquera AM, Gonzalez E, Lozano J, Ingham M, Dohm JC, Noguera M, Kofler R, Del Rio JA, Bayes M, Himmelbauer H, Sumoy L. Multiple platform assessment of the EGF dependent transcriptome by microarray and deep tag sequencing analysis. BMC Genomics. 2011 Jun 23;12(1):326. [Epub ahead of print] link


Brouard S, Puig-Pey I, Lozano JJ, Pallier A, Braud C, Giral M, Guillet M,Londono MC, Oppenheimer F, Campistol JM, Soulillou JP, Sanchez-Fueyo A.
Comparative Transcriptional and Phenotypic Peripheral Blood Analysis of Kidney Recipients Under Cyclosporin A or Sirolimus Monotherapy. Am J Transplant. 2010 Dec;10(12):2604-2614. doi:10.1111/j.1600-6143.2010.03302.x. pdf


Ko KS, Tomasi ML, Iglesias-Ara A, French BA, French SW, Ramani K, Lozano JJ, Oh P, He L, Stiles BL, Li TW, Yang H, Martínez-Chantar ML, Mato JM, Lu SC. Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice. Hepatology. 2010 Aug 20. [Epub ahead of print] pdf


Benítez CE, Puig-Pey I, López M, Martínez-Llordella M,Lozano JJ, Bohne F, Londono MC, García-Valdecasas JC, Bruguera M, Navasa M, Rimola A,Sánchez-Fueyo A.
ATG-Fresenius Treatment and Low-Dose Tacrolimus: Results of a Randomized Controlled Trial in Liver Transplantation. Am J Transplant. 2010 Oct;10(10):2296-304 pdf


Balaguer F, Link A, Lozano JJ, Cuatrecasas M, Nagasaka T, Boland CR, Goel A.
Epigenetic Silencing of miR-137 Is an Early Event in Colorectal Carcinogenesis. Cancer Res. 2010 Aug 3. [Epub ahead of print] pdf


Link A, Balaguer F, Shen Y, Nagasaka T, Lozano JJ, Boland CR, Goel A.
Fecal MicroRNAs as Novel Biomarkers for Colon Cancer Screening. Cancer Epidemiol Biomarkers Prev. 2010 Jun 15. [Epub ahead of print]


Pallier A, Hillion S, Danger R, Giral M, Racapé M, Degauque N, Dugast E,Ashton-Chess J, Pettré S,Lozano JJ, Bataille R, Devys A, Cesbron-Gautier A, Braudeau C, Larrose C, Soulillou JP, Brouard S.
Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype. Kidney Int. 2010 Jun 9. [Epub ahead of print] pdf


Puig-Pey I, Bohne F, Benítez C, López M, Martínez-Llordella M, Oppenheimer F,Lozano JJ, González-Abraldes J, Tisone G, Rimola A, Sánchez-Fueyo A. Characterization of gammadelta T cell subsets in organ transplantation.
Transpl Int. 2010 May 5. [Epub ahead of print]


Titos E, Ferré N, Lozano JJ, Horrillo R, López-Parra M, Arroyo V, Clària J.
Protection From Hepatic Lipid Accumulation And Inflammation By Genetic Ablation Of 5-Lipoxygenase.
Prostaglandins Other Lipid Mediat. 2010 Mar 11. PMID: 20227514 link


Moreno M, Chaves JF, Sancho-Bru P, Ramalho F, Ramalho LN, Mansego ML, Ivorra C, Dominguez M, Conde L, Millán C, Marí M, Colmenero J, Lozano JJ, Jares P, Vidal J, Forns X, Arroyo V, Caballería J, Ginès P, Bataller R.
Ghrelin attenuates hepatocellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans.
Hepatology. 2010 Mar;51(3):974-85.PMID: 20077562 link


Armengol G, Knuutila S, Lozano JJ, Madrigal I, Caballín MR.
Identification of human specific gene duplications relative to other primates by array CGH and quantitative PCR.
Genomics. 2010 Feb 11. PMID: 20153417 link


Tingaud-Sequeira A, Calusinska M, Finn RN, Chauvigné F, Lozano J, Cerdà J.
The zebrafish genome encodes the largest vertebrate repertoire of functional aquaporins with dual paralogy and substrate specificities similar to mammals.
BMC Evol Biol. 2010 Feb 11;10:38.PMID: 20149227 link


Gonzalo V, Lozano JJ, Munoz J, Balaguer F, Pellisé M, Rodríguez de Miguel C, Andreu M, Jover R, Llor X, Giráldez MD, Ocaña T, Serradesanferm A, Alonso-Espinaco V, Jimeno M, Cuatrecasas M, Sendino O, Castellví-Bel S, Castells A; Gastrointestinal Oncology Group of the Spanish Gastroenterological Association.
Aberrant gene promoter methylation associated with sporadic multiple colorectal cancer.
PLoS One. 2010 Jan 19;5(1):e8777.PMID: 20098741 link


Soler M, Mancini F, Meca-Cortés O, Sánchez-Cid L, Rubio N, López-Fernández S, Lozano JJ, Blanco J, Fernández PL, Thomson TM.
HER3 is required for the maintenance of neuregulin-dependent and -independent attributes of malignant progression in prostate cancer cells.
Int J Cancer. 2009 Dec 1;125(11):2565-75.PMID: 19530240 link pdf


Tingaud-Sequeira A, Chauvigné F, Lozano J, Agulleiro MJ, Asensio E, Cerdà J.
New insights into molecular pathways associated with flatfish ovarian development and atresia revealed by transcriptional analysis.
BMC Genomics. 2009 Sep 15;10:434.PMID: 19754951 link


Mengual L, Burset M, Ars E, Lozano JJ, Villavicencio H, Ribal MJ, Alcaraz A.
DNA microarray expression profiling of bladder cancer allows identification of noninvasive diagnostic markers.
J Urol. 2009 Aug;182(2):741-8. Epub 2009 Jun 18.PMID: 19539325 link


Benítez C, Lozano JJ, Fueyo AS.
Gene expression profiling and transplantation tolerance in the clinic.
Transplantation. 2009 Aug 15;88(3 Suppl):S50-3. Review.PMID: 19667962 link


Servitja JM, Pignatelli M, Maestro MA, Cardalda C, Boj SF,Lozano J, Blanco E, Lafuente A, McCarthy MI ,Sumoy L, Guigó R, Ferrer J.
Hnf1~ (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver.
Molecular Cell Biology 2009 Jun;29(11):2945-59.


Muñoz MJ, Pérez Santangelo MS, Paronetto MP, de la Mata M, Pelisch F, Boireau S, Glover-Cutter K, Ben-Dov C, Blaustein M, Lozano JJ, Bird G, Bentley D, Bertrand E, Kornblihtt AR.
DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation.
Cell. 2009 May 15;137(4):708-20. Erratum in: Cell. 2009 Oct 2;139(1):211. PMID: 19450518 link


Martinez-Llordella M, Lozano JJ, Puig-Pey I, Orlando G, Tisone G, Lerut J, Benitez C, Pons JA, Parrilla P, Ramírez P, Bruguera M, Rimola A, Sánchez-Fueyo A.
Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients.
J Clin Invest. 2008 Jul 24. link


Puigdecanet E, Espinet B, Lozano JJ, Sumoy L, Bellosillo B, Arenillas L, Alvarez-Larran A, Sole F, Serrano S, Besses C, Florensa L.
Gene expression profiling distinguishes JAK2V617F-negative from JAK2V617F-positive patients in essential thrombocythemia.
Leukemia. 2008 Jul;22(7):1368-76 link


Saenz L, Lozano JJ, Valdor R, Baroja-Mazo A, Ramirez P, Parrilla P, Aparicio P, Sumoy L, Yélamos J.
Transcriptional regulation by poly(ADP-ribose) polymerase-1 during T cell activation.
BMC Genomics. 2008, 9:171 link


Mercader JM, Lozano JJ, Sumoy L, Dierssen M, Visa J, Gratacos M, Estivill X.
Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx/anx mouse model.
Physiol Genomics. 2008 Sep 23. pdf


Tingaud-Sequeira A, Chauvigné F, Fabra M,Lozano J Raldúa D, Cerdà J.
Structural and functional divergence of two fish aquaporin-1 water channels following teleost-specific gene duplication.
BMC Evol Biol. 2008 Sep 23;8:259. link


Cerdà J, Mercade J,,Lozano JJ, Manchado M, Tingaud-Sequeira A, Astola A, Infante C, Halm S, Vinas J, Castellana B, Asensio E, Canavate P, Martinez-Rodriguez G, Piferrer F, Planas JV, Prat F, Yufera M, Durany O, Subirada F, Rosell E and Maes T
BMC Genomics 2008, 9:508 link